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KMID : 1140120100150030211
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Cancer Prevention Research
2010 Volume.15 No. 3 p.211 ~ p.216
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Effects of Sea Tangle Supplement and Regular Treadmill Exercise on Anti-inflammatory Effect Following Exhaustive Exercise Stress
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Park Cheol
Kim Hyang-Suk
Kwak Yi-Sub
Choi Young-Hyun
Kang Se-Na
Park Jung-Hwa
Hwang Hye-Jin
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Abstract
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1Blue-Bio Industry Regional Innovation Center, Departments of 2Food and Nutrition, 3Physical Education, 4Oriental Medicine and Biomaterial Control (BK21), and Research Institute of Oriental Medicine, Dongeui University, Busan 614-052, 5Dongeui Food Research Institute, Busan 614-714, 6Department of Food and Nutrition, Yonsei University, Seoul 120-749, Korea In this study, we examined the effects of Sea Tangle (Laminaria japonica) supplementation and regular exercise on the expression of anti-inflammatory mediators in liver of stress-stimulated rat. Stress significantly induced inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in the liver, however Sea Tangle supplementation and regular exercise significantly inhibited stress-induced the levels of iNOS and COX-2 proteins. To investigate the mechanism by which Sea Tangle supplementation and regular exercise inhibited iNOS and COX-2 expression, we examined the extent of IkappaB (IκB) degradation. Sea Tangle supplementation and regular exercise significantly attenuated the stress-induced IκB degradation. Taken together, these findings provide important new insights that Sea Tangle supplementation and regular exercis exhibits anti-inflammatory properties by suppressing the transcription of pro-inflammatory cytokine genes through the nuclear factor-kappaB (NF-κB) signaling pathway.
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KEYWORD
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Sea tangle, Exercise, iNOS, COX-2, IκB
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